Profhilo® is a ground-breaking injectable product used in anti-aging medicine. It represents the first-ever made product that contains stabilized hyaluronic acid and isn’t manufactured with chemical cross-linking agents. It is a revolutionary treatment that treats skin laxity, fills the lines and wrinkles and remodels the skin. It improves skin tone, texture, hydration and overall radiance. It can help to increase the firmness and elasticity of the skin and promote healthier and softer-looking skin. It can dramatically improve the quality of the skin’s tissue and can be used with other aesthetic treatments and dermal fillers.

‍Profhilo® is manufactured by IBSA Farmaceutici Italia in a U.S. FDA approved site in Italy, and distributed in the UK & Ireland by HA-Derma Ltd.

It is the first stabilized hyaluronic acid (HA) based product which is manufactured without the use of chemical cross-linking agents (BDDE) and is used for skin remodeling and treating skin laxity, not for just filling lines and wrinkles. According to the makers, it delivers dramatic improvement in tissue quality, even in challenging areas, and is complementary to other aesthetic treatments and dermal filler procedures.

It is safe, effective and “a true breakthrough” in anti-ageing medicine.

Procedure info at a glance

Is it painful? No since anesthetic cream is used
Is there any downtime? Possibility of mild swelling, redness and soreness after injection
How many sessions are needed? Usually 2 to 3 sessions
How long does the procedure take? Around 20 minutes
When can I see the results? After the course of sessions
How often should I do it? Every 4 weeks

How It Works


Because it’s a pure hyaluronic acid. A patented bio-fermentation process is used to manufacture it which makes it absolutely safe and resistant to thermal production processes. The concept of Hydrolift® Action produces hyaluronic acid of different molecular weights and makes Profhilo® the best in preventing the reduction of HA, restoring hydration, skin tone and elasticity. It deeply hydrates the skin but also lifts it.

Profhilo doesn’t consist of butanediol diglycidyl (BDDE) or a synthetic chemical, any impurities or additives. It has the highest concentration of HA on the market which makes it one of the most successful products for aging and sagging skin remodeling. It provides natural results with minimal to no discomfort and downtime.

It is an injectable treatment that makes the skin absorb the HA uniformly, evenly and effectively. Profhilo® rejuvenates and restores the skin from the inside.


As the skin gets older it loses elastin and collagen, the proteins that ensure that the skin is firm. The wrinkles and fine lines start to appear as the skin loses its structure.

What makes Profhilo special is that it solves the problem at the very root – it triggers collagen and elastin production and increases the skin’s elasticity.

Profhilo® slowly releases the hyaluronic acid and it improves the skin elasticity, treats wrinkles and boosts the quality of the tissue and it triggers the production of elastin and collagen. This way it improves hydration, skin tone and reduces fine lines. This process is also known as bio-remodeling – Profhilo® makes the body regenerate its cells and it impacts the appearance.

Profhilo® hydrates the tired, dull skin and turns it into firm and shiny. Since it releases hyaluronic acid, Profhilo® draws and holds water from the body. After the treatment, collagen and elastin are produced which actually delivers the secondary skin tightening effect. Profhilo® reverses the signs of aging because the levels of hyaluronic acid, collagen and elastin drop as the skin gets more and more mature. Fine lines and wrinkles and dull skin are greatly improved.


Hyaluronic acid is already present in the body and its levels are regulated by the enzyme hyaluronidase – it breaks down the HA molecules. This enzyme also breaks down Profhilo® over time, but it doesn’t leave any trace of this product as it is completely natural.

Hyaluronic acid is very powerful -a fact that not many people know. It can draw 1000 its own weight in water into the skin. This is what makes it perfect for hydrating the skin from the inside, maintaining water molecules and keeping the skin radiant and fresh.

During the Profhilo® treatment, this product is injected on both sides of the face at five injection points. When injected, Profhilo® evenly spreads allover the skin layers and draws water on its way. The results are seen all over the face which gives a more even and younger-looking effect.


It is an advanced minimally invasive procedure that requires no downtime and achieves amazing results.

Profhilo® improves skin texture, tone, hydration and general radiance. It boosts elasticity and firmness and archives softer-looking and healthier skin.

It is usually used for the face but it can achieve dramatic improvements on other body parts as well.

It stimulates the production of elastin and collagen and constantly hydrates the skin which gives it a fresher feel and look. It can be used as prevention to avoid dullness and loss of skin volume.

It is one of the best products on the market because of the highest concentration of HA on the market. It remodels sagging and aging tissue and improves skin laxity.

It is suitable for both men and women and can also help patients of all ages to rejuvenate their skin.


Depending on the patient’s needs and treatment goals, Profhilo® can be used together with Dermal Fillers to ensure radiant and healthy complexion and enhance the results of fillers. Profhilo® hydrates the skin and softens wrinkles and fine lines. It is a perfect solution for smoothing skin texture and getting a radiant complexion. If on the other hand patients wish to restore the lost volume in the skin and return a nicely balanced profile, dermal fillers are a good option. But, combined, dermal fillers and Profhilo® can achieve amazing results.

Profhilo® is a fast and effective treatment and its benefits represent a revolution in cosmetic and aesthetic procedures.



    Anybody who wishes to get radiant skin by naturally stimulating elastin and collagen production and hydrating the skin.

    Profhilo® can help rejuvenate:

    FACE - especially the cheeks (or malar area), under the cheeks (or sub-malar area), fine lines around the lips and marionette lines (the ones that go from the corners of the lips downward). Also, wrinkles under the eyes and around the eyes (crow’s feet and frown lines).


    NECK - it can lift and tighten thin and crepey skin.



    Profhilo® enhances dull, dehydrated skin and helps sunken skin to get more volume.

    Profhilo® can be used as a preventive measure for patients in the late20s and 30s who want to stimulate the natural cell rejuvenation which in turn produces clearer, fresher and glowing skin.

    This cutting-edge anti-aging injectable treatment can be used for men to rejuvenate, hydrate and stimulate collagen production.


    Even though Profhilo® is a safe product there are some people who are not recommended to use it:

    If they are allergic to Hyaluronic Acid.

    If they suffer from bleeding and blood disorders.

    If they are sensitive to gram-positive bacteria proteins.

    If they have infection or inflammation on the targeted skin areas.

    If they have facial treatments in progress like chemical peels, microdermabrasion or laser procedures.

    If they have cold sores.

    Women who are pregnant and breastfeeding.

    If they want to have facial surgery in the next 12 months.


    Upon arriving at Lucia Clinic patients are first consulted with the therapists who are specialists in Profhilo® treatments. They discuss patients' needs and goals and what they want to achieve with the treatment. The therapists carefully assess the patients' faces to see if they are good candidates for this treatment. Together with the patients, the therapists make a custom-tailored treatment plan, especially for them. Lucia’s Team of specialists has only one goal in mind - to provide the patients the best results.


    A numbing cream is applied to the patient’s face to ensure maximum comfort. The therapist marks the areas that will be treated and then injects the Profhilo® with a fine needle.

    Profhilo® is injected into exact spots just beneath the skin. This technique is called the Bio Aesthetic Points technique or BAP. This collagen enhancing liquid is administered in five spots on both sides of the face - next to the ears, nasolabial fold, under the eyes, chin and on the top of the cheeks. This technique ensures a maximal diffusion of the liquid in the sub-malar and malar areas so the Profhilo® spreads out evenly because of high HA concentration and its cohesive character.

    Profhilo® is absorbed by the skin in the area of 2cm from the injection point. To treat the whole face, 10 injections points are necessary.

    The treatment is finished in approximately 30 minutes.


    Since the treatment is minimally invasive it produces minimal discomfort. The needles feel like mild stinging but this feeling lasts for 20seconds. The injections are administered slowly and gently to ensure maximum comfort of the patients.


    After the Profhilo® procedure is finished, there are no signs of injections so there is no downtime. Patients can return to their everyday routine straight away. The patients are advised not to touch or apply makeup on the treated areas for 6 hours to avoid infection. The targeted areas may appear a little bumpy but this seizes in a few hours. Strenuous exercise is also not recommended after the treatment.

    Also, mild bruising, swelling and tenderness might appear but after a few days, the skin is youthful-looking and plump.


    Usually, after six months the HA in Profhilo® breaks down naturally in the body. However, this can vary from patient to patient all depending on the amount of Profhilo® injected and the natural level of HA in the body. Overall, the optimal results of the treatment will be visible from 3 to 18 months, after the HA breaks down.

    The hydrating starts 3 to 5 days post-treatment. The best results of Profhilo® are visible 2 months after the second session.

    The results include increased firmness, elasticity and improvement of the skin appearance.

    Usually, two treatment sessions are recommended at first with one month apart. Patients can get additional touch-ups to maintain the results but this is done if the Profhilo® therapist recommends it. It all depends on how the patient’s body responds to the procedure.